Ontology highlight
ABSTRACT:
SUBMITTER: Krishnamoorthy A
PROVIDER: S-EPMC5572759 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Archives of biochemistry and biophysics 20170725
Wnt signaling is essential for embryonic development and adult homeostasis in multicellular organisms. A conserved feature among Wnt family proteins is the presence of two structural domains. Within the N-terminal (NT) domain there exists a motif that is superimposable upon saposin-like protein (SAPLIP) family members. SAPLIPs are found in plants, microbes and animals and possess lipid surface seeking activity. To investigate the function of the Wnt3a saposin-like subdomain (SLD), recombinant SL ...[more]