Ontology highlight
ABSTRACT:
SUBMITTER: Le NDB
PROVIDER: S-EPMC5572768 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Le Ngoc D B NDB Wang Xian X Geng Yingying Y Tang Rui R Tonga Gulen Yesilbag GY Jiang Ziwen Z Rotello Vincent M VM
Chemical communications (Cambridge, England) 20170724 62
Endocrine disrupting chemicals (EDCs) interact with estrogen receptors (ERs), causing a broad range of adverse health effects. Current assays for EDC activity are slow and often lack sensitivity. We report here an ultra-sensitive nanosensor that can detect estrogenic cellular changes in ER(+) MCF-7 cells rapidly (minutes) at several orders of magnitude lower than the generally used assays. Notably, the sensor responses at these ultra-low EDC levels correlated with an increased synthesis phase (S ...[more]