Ontology highlight
ABSTRACT:
SUBMITTER: Goyal MS
PROVIDER: S-EPMC5573225 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Goyal Manu S MS Vlassenko Andrei G AG Blazey Tyler M TM Su Yi Y Couture Lars E LE Durbin Tony J TJ Bateman Randall J RJ Benzinger Tammie L-S TL Morris John C JC Raichle Marcus E ME
Cell metabolism 20170801 2
The normal aging human brain experiences global decreases in metabolism, but whether this affects the topography of brain metabolism is unknown. Here we describe PET-based measurements of brain glucose uptake, oxygen utilization, and blood flow in cognitively normal adults from 20 to 82 years of age. Age-related decreases in brain glucose uptake exceed that of oxygen use, resulting in loss of brain aerobic glycolysis (AG). Whereas the topographies of total brain glucose uptake, oxygen utilizatio ...[more]