Intravenous Fluid Challenge Decreases Intracellular Volume: A Bioimpedance Spectroscopy-Based Crossover Study in Healthy Volunteers.

ABSTRACT: The effects of intravenous fluid therapy on fluid compartments and hemodynamics of the human body remain enigmatic. We therefore tested the efficacy of bioimpedance spectroscopy in a crossover study, where 15 males received 0.5?ml/kg/min ELO-MEL-isoton (osmolarity?=?302 mosmol/l) during 60?minutes, or nothing at all. In group "Fluid", fluid load increased from -0.2?±?1.0?l extracellular volume at baseline to its maximum of 1.0?±?0.9?l in minute 70, and remained continuously elevated throughout minute 300. In group "Zero", fluid load decreased from 0.5?±?1.1?l at baseline to its minimum of -1.1?±?1.1?l in minute 300. In group "Fluid", intracellular volume decreased from 26.8?±?3.9?l at baseline to its minimum of 26.0?±?3.9?l in minute 70, and remained continuously decreased throughout minute 300. In group "Zero", intracellular volume increased from 26.5?±?3.8?l at baseline to its maximum of 27.1?±?3.9?l in minute 120, and decreased thereafter. In group "Fluid" compared to "Zero", systolic blood pressure was significantly higher, from minute 50-90. In conclusion, intravenous fluid therapy caused a clinically meaningful, sustained increase in fluid load, and a decrease in intracellular volume. These data raise interest in studying fluid administration by the gastrointestinal route, perhaps even when managing critical illness.

SUBMITTER: Ernstbrunner M 

PROVIDER: S-EPMC5575097 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature