Ontology highlight
ABSTRACT:
SUBMITTER: Goni F
PROVIDER: S-EPMC5575137 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Goñi Fernando F Martá-Ariza Mitchell M Peyser Daniel D Herline Krystal K Wisniewski Thomas T
Scientific reports 20170829 1
We describe a novel approach to produce conformational monoclonal antibodies selected to specifically react with the β-sheet secondary structure of pathological oligomeric conformers, characteristic of many neurodegenerative diseases. Contrary to past and current efforts, we utilize a mammalian non-self-antigen as an immunogen. The small, non-self peptide selected was covalently polymerized with glutaraldehyde until it reached a high β-sheet secondary structure content, and species between 10-10 ...[more]