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ABSTRACT: Introduction
Interleukin-21 (IL-21) is a cytokine which plays a significant role in the pathogenesis and disease activity of rheumatoid arthritis (RA). Genetic polymorphisms in the IL-21 gene may alter the synthesis of IL-21. The aim of this study was to examine IL-21 and IL-21R polymorphisms in patients with RA.Material and methods
We examined 422 patients with RA and 338 healthy controls. Single nucleotide polymorphisms (SNPs) within the IL-21 (rs6822844 G>T, rs6840978 C>T, rs2221903 T>C) and IL-21R (rs2285452 G>A) genes were genotyped using TaqMan genotyping assays.Results
There were no statistically significant differences in the distribution of studied genotypes and alleles between RA patients and the control group. To examine whether IL-21 polymorphisms affect disease activity in RA patients, we compared the distribution of IL-21 genotypes between patients with DAS28 ≤ 2.5 (patients with remission of disease symptoms) and patients with DAS28 > 2.5 (patients with active RA). Among patients with DAS28 > 2.5, increased prevalence of rs2221903 CT and CC genotypes was observed (OR = 1.54; 95% CI: 1.04-2.28; p = 0.035).Conclusions
The results of this study suggest that IL-21 and IL-21R gene polymorphisms are not risk loci for RA susceptibility, whereas the IL-21 rs2221903 polymorphism is associated with disease activity.
SUBMITTER: Malinowski D
PROVIDER: S-EPMC5575225 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Malinowski Damian D Paradowska-Gorycka Agnieszka A Safranow Krzysztof K Pawlik Andrzej A
Archives of medical science : AMS 20170717 5
<h4>Introduction</h4>Interleukin-21 (IL-21) is a cytokine which plays a significant role in the pathogenesis and disease activity of rheumatoid arthritis (RA). Genetic polymorphisms in the <i>IL-21</i> gene may alter the synthesis of IL-21. The aim of this study was to examine IL-21 and IL-21R polymorphisms in patients with RA.<h4>Material and methods</h4>We examined 422 patients with RA and 338 healthy controls. Single nucleotide polymorphisms (SNPs) within the <i>IL-21</i> (rs6822844 G>T, rs68 ...[more]