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Plasma interleukin-21 levels and genetic variants are associated with susceptibility to rheumatoid arthritis.


ABSTRACT:

Background

Rheumatoid Arthritis (RA) is a chronic inflammatory condition characterized by autoantibodies development and an elevated spectrum of pro-inflammatory cytokines. Previous reports highlighted a relationship between IL-21and the pathogenesis of RA. Although elevated IL-21 levels have been reported in RA patients, the association of common IL-21 genetic variants with a predisposition to RA development in the Chinese population lacks.

Materials and methods

Five hundred and fourteen Chinese subjects (healthy controls: 303 and rheumatoid arthritis patients: 211) were enrolled in the study. Clinical data of patients were collected from medical records, and patients were treated as per the guidelines. Common single nucleotide polymorphisms in the IL-21 gene (rs907715, rs2221903, rs2055979 and rs6822844) were genotyped by TaqMan SNPs genotyping method. IL-21 level in plasma of RA patients and healthy subjects was measured by ELISA.

Results

The plasma level of IL-21 was significantly higher in subjects with rheumatoid arthritis relative to healthy controls (p?ConclusionIL-21 plays a crucial function in rheumatoid arthritis pathogenesis. IL-21 rs2055979 polymorphism is associated with IL-21 plasma levels and is predisposed to RA development in the Chinese population.

SUBMITTER: Hao Y 

PROVIDER: S-EPMC7936495 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Publications

Plasma interleukin-21 levels and genetic variants are associated with susceptibility to rheumatoid arthritis.

Hao Youguo Y   Xie Lijun L   Xia Jing J   Liu Zhen Z   Yang Baoxiu B   Zhang Minqin M  

BMC musculoskeletal disorders 20210305 1


<h4>Background</h4>Rheumatoid Arthritis (RA) is a chronic inflammatory condition characterized by autoantibodies development and an elevated spectrum of pro-inflammatory cytokines. Previous reports highlighted a relationship between IL-21and the pathogenesis of RA. Although elevated IL-21 levels have been reported in RA patients, the association of common IL-21 genetic variants with a predisposition to RA development in the Chinese population lacks.<h4>Materials and methods</h4>Five hundred and  ...[more]

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