End stage renal disease-induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived-matrix vesicles.
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ABSTRACT:
SUBMITTER: Cui L
PROVIDER: S-EPMC5575563 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
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End stage renal disease-induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived-matrix vesicles.
Cui Lin L Rashdan Nabil A NA Zhu Dongxing D Milne Elspeth M EM Ajuh Paul P Milne Gillian G Helfrich Miep H MH Lim Kelvin K Prasad Sai S Lerman Daniel A DA Vesey Alex T AT Dweck Marc R MR Jenkins William S WS Newby David E DE Farquharson Colin C Macrae Vicky E VE
Journal of cellular physiology 20170524 11
Patients with end-stage renal disease (ESRD) have elevated circulating calcium (Ca) and phosphate (Pi), and exhibit accelerated progression of calcific aortic valve disease (CAVD). We hypothesized that matrix vesicles (MVs) initiate the calcification process in CAVD. Ca induced rat valve interstitial cells (VICs) calcification at 4.5 mM (16.4-fold; p < 0.05) whereas Pi treatment alone had no effect. Ca (2.7 mM) and Pi (2.5 mM) synergistically induced calcium deposition (10.8-fold; p < 0.001) in ...[more]
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