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High-speed photoacoustic microscopy of mouse cortical microhemodynamics.

ABSTRACT: We applied high-speed photoacoustic microscopy (PAM) for both cortical microenvironment studies and dynamic brain studies, with micrometer-level optical resolution and a millisecond-level cross-sectional imaging speed over a millimeter-level field of view. We monitored blood flow redistribution in mini-stroke mouse models and cerebral autoregulation induced by a vasoactive agent. Our results collectively suggest that high-speed PAM is a promising tool for understanding dynamic neurophysiological phenomena, complementing conventional imaging modalities.

SUBMITTER: Lin L

PROVIDER: S-EPMC5576888 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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High-speed photoacoustic microscopy of mouse cortical microhemodynamics.

Lin Li L Yao Junjie J Zhang Ruiying R Chen Chun-Cheng CC Huang Chih-Hsien CH Li Yang Y Wang Lidai L Chapman William W Zou Jun J Wang Lihong V LV

Journal of biophotonics 20161223 6-7

We applied high-speed photoacoustic microscopy (PAM) for both cortical microenvironment studies and dynamic brain studies, with micrometer-level optical resolution and a millisecond-level cross-sectional imaging speed over a millimeter-level field of view. We monitored blood flow redistribution in mini-stroke mouse models and cerebral autoregulation induced by a vasoactive agent. Our results collectively suggest that high-speed PAM is a promising tool for understanding dynamic neurophysiological ...[more]

PMID: 28009098

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