Ontology highlight
ABSTRACT:
SUBMITTER: Gugliotta G
PROVIDER: S-EPMC5576979 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Gugliotta Gabriele G Sudo Makoto M Cao Qi Q Lin De-Chen DC Sun Haibo H Takao Sumiko S Le Moigne Ronan R Rolfe Mark M Gery Sigal S Müschen Markus M Cavo Michele M Koeffler H Phillip HP
Neoplasia (New York, N.Y.) 20170829 10
B acute lymphoblastic leukemia (B-ALL) cells are distinctively vulnerable to endoplasmic reticulum (ER) stress. Recently, inhibition of p97 was shown to induce ER stress and subsequently cell death in solid tumors and in multiple myeloma. We investigated the role of a novel, orally available, p97 inhibitor (CB-5083; Cleave Biosciences) in B-ALL. CB-5083 induced a significant reduction in viability in 10 human B-ALL cell lines, harboring the most common fusion-genes involved in pediatric and adul ...[more]