Ontology highlight
ABSTRACT:
SUBMITTER: Di Q
PROVIDER: S-EPMC5577445 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Open biology 20170801 8
Neutrophils play important roles in innate immunity and are mainly dependent on various enzyme-containing granules to kill engulfed microorganisms. Zebrafish <i>nephrosin</i> (<i>npsn</i>) is specifically expressed in neutrophils; however, its function is largely unknown. Here, we generated an <i>npsn</i> mutant (<i>npsn<sup>smu5</sup></i> ) via CRISPR/Cas9 to investigate the <i>in vivo</i> function of Npsn. The overall development and number of neutrophils remained unchanged in <i>npsn</i>-defi ...[more]