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Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069.


ABSTRACT: Two new alkaloids, strepchazolins A (1) and B (2), together with a previously reported compound, streptazolin (3), were isolated from a marine actinomycete, Streptomyces chartreusis NA02069, collected in the Coast of Hainan Island, China. The structures of new compounds were determined by extensive NMR, mass spectroscopic and X-ray crystallographic analysis, as well as modified Mosher's method. Compound 1 showed weak anti-Bacillus subtilis activity with the MIC value of 64.0 ?M, and weak inhibitory activity against acetylcholinesterase (AChE) in vitro with IC50 value of 50.6 ?M, while its diastereoisomer, Compound 2, is almost inactive.

SUBMITTER: Yang CL 

PROVIDER: S-EPMC5577599 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069.

Yang Cheng-Long CL   Wang Yi-Shuang YS   Liu Cheng-Li CL   Zeng Ying-Jie YJ   Cheng Ping P   Jiao Rui-Hua RH   Bao Shi-Xiang SX   Huang Hui-Qin HQ   Tan Ren-Xiang RX   Ge Hui-Ming HM  

Marine drugs 20170802 8


Two new alkaloids, strepchazolins A (<b>1</b>) and B (<b>2</b>), together with a previously reported compound, streptazolin (<b>3</b>), were isolated from a marine actinomycete, <i>Streptomyces chartreusis</i> NA02069, collected in the Coast of Hainan Island, China. The structures of new compounds were determined by extensive NMR, mass spectroscopic and X-ray crystallographic analysis, as well as modified Mosher's method. Compound <b>1</b> showed weak anti-<i>Bacillus subtilis</i> activity with  ...[more]

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