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Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069.

ABSTRACT: Two new alkaloids, strepchazolins A (1) and B (2), together with a previously reported compound, streptazolin (3), were isolated from a marine actinomycete, Streptomyces chartreusis NA02069, collected in the Coast of Hainan Island, China. The structures of new compounds were determined by extensive NMR, mass spectroscopic and X-ray crystallographic analysis, as well as modified Mosher's method. Compound 1 showed weak anti-Bacillus subtilis activity with the MIC value of 64.0 ?M, and weak inhibitory activity against acetylcholinesterase (AChE) in vitro with IC₅₀ value of 50.6 ?M, while its diastereoisomer, Compound 2, is almost inactive.

SUBMITTER: Yang CL

PROVIDER: S-EPMC5577599 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069.

Yang Cheng-Long CL Wang Yi-Shuang YS Liu Cheng-Li CL Zeng Ying-Jie YJ Cheng Ping P Jiao Rui-Hua RH Bao Shi-Xiang SX Huang Hui-Qin HQ Tan Ren-Xiang RX Ge Hui-Ming HM

Marine drugs 20170802 8

Two new alkaloids, strepchazolins A (1) and B (2), together with a previously reported compound, streptazolin (3), were isolated from a marine actinomycete, Streptomyces chartreusis NA02069, collected in the Coast of Hainan Island, China. The structures of new compounds were determined by extensive NMR, mass spectroscopic and X-ray crystallographic analysis, as well as modified Mosher's method. Compound 1 showed weak anti-Bacillus subtilis activity with ...[more]

PMID: 28767052

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