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Anandins A and B, Two Rare Steroidal Alkaloids from a Marine Streptomyces anandii H41-59.

ABSTRACT: Anandins A (1) and B (2), two rare steroidal alkaloids, were isolated from the fermentative broth of a marine actinobacteria Streptomyces anandii H41-59. The gross structures of the two alkaloids were elucidated by spectroscopic methods including HR-ESI-MS, and NMR. Their absolute configurations were confirmed by single-crystal X-ray diffraction analysis and comparison of their experimental and calculated electronic circular dichroism spectra, respectively. Anandin A exhibited a moderate inhibitory effect against three human cancer cell lines MCF-7, SF-268, and NCI-H460 with IC50 values of 7.5, 7.9, 7.8 ?g/mL, respectively.

SUBMITTER: Zhang YM

PROVIDER: S-EPMC5706044 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Anandins A and B, Two Rare Steroidal Alkaloids from a Marine Streptomyces anandii H41-59.

Zhang Yang-Mei YM Liu Bai-Lian BL Zheng Xin-Heng XH Huang Xiao-Jun XJ Li Hong-Yu HY Zhang Ying Y Zhang Ting-Ting TT Sun Da-Yuan DY Lin Bi-Run BR Zhou Guang-Xiong GX

Marine drugs 20171110 11

Anandins A (1) and B (2), two rare steroidal alkaloids, were isolated from the fermentative broth of a marine actinobacteria Streptomyces anandii H41-59. The gross structures of the two alkaloids were elucidated by spectroscopic methods including HR-ESI-MS, and NMR. Their absolute configurations were confirmed by single-crystal X-ray diffraction analysis and comparison of their experimental and calculated electronic circular dichroism spectra, respectively. Anandin A exhibit ...[more]

PMID: 29125577

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