Ontology highlight
ABSTRACT:
SUBMITTER: Spies N
PROVIDER: S-EPMC5578891 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Spies Noah N Weng Ziming Z Bishara Alex A McDaniel Jennifer J Catoe David D Zook Justin M JM Salit Marc M West Robert B RB Batzoglou Serafim S Sidow Arend A
Nature methods 20170717 9
In read cloud approaches, microfluidic partitioning of long genomic DNA fragments and barcoding of shorter fragments derived from these fragments retains long-range information in short sequencing reads. This combination of short reads with long-range information represents a powerful alternative to single-molecule long-read sequencing. We develop Genome-wide Reconstruction of Complex Structural Variants (GROC-SVs) for SV detection and assembly from read cloud data and apply this method to Illum ...[more]