Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC5579017 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Zhao Yanyan Y Wei Junfang J Hou Xuefeng X Liu Huimiao H Guo Feng F Zhou Yingni Y Zhang Yuanyuan Y Qu Yunhui Y Gu Junfei J Zhou Yuanli Y Jia Xiaobin X Qin Guijun G Feng Liang L
Scientific reports 20170831 1
SIRT1 and FOXO1 play an important role in the pathogenesis of diabetic nephropathy (DN). However, the association between genetic polymorphisms and susceptibility to type 2 DN (T2DN) has not been explored. In this study, a total of 1066 patients with type 2 diabetes mellitus (T2DM) (413 without and 653 with DN) were enrolled. The genotypes of three htSNPs (rs3818292, rs4746720, rs10823108) within SIRT1 and two htSNPs (rs2721068, rs17446614) in FOXO1 were determined by PCR-RFLP. HbA1C, LDL, HDL, ...[more]