Ontology highlight
ABSTRACT:
SUBMITTER: Gurley SB
PROVIDER: S-EPMC6152345 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Gurley Susan B SB Ghosh Sujoy S Johnson Stacy A SA Azushima Kengo K Sakban Rashidah Binte RB George Simi E SE Maeda Momoe M Meyer Timothy W TW Coffman Thomas M TM
Diabetes 20180731 10
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease worldwide, but its molecular pathogenesis is not well defined, and there are no specific treatments. In humans, there is a strong genetic component determining susceptibility to DN. However, specific genes controlling DN susceptibility in humans have not been identified. In this study, we describe a mouse model combining type 1 diabetes with activation of the renin-angiotensin system (RAS), which develops robust kidney disea ...[more]