Ontology highlight
ABSTRACT:
SUBMITTER: Herbert S
PROVIDER: S-EPMC5579376 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Herbert Sébastien S Brion Alice A Arbona Jean-Michel JM Lelek Mickaël M Veillet Adeline A Lelandais Benoît B Parmar Jyotsana J Fernández Fabiola García FG Almayrac Etienne E Khalil Yasmine Y Birgy Eleonore E Fabre Emmanuelle E Zimmer Christophe C
The EMBO journal 20170710 17
DNA double-strand breaks (DSBs) induce a cellular response that involves histone modifications and chromatin remodeling at the damaged site and increases chromosome dynamics both locally at the damaged site and globally in the nucleus. In parallel, it has become clear that the spatial organization and dynamics of chromosomes can be largely explained by the statistical properties of tethered, but randomly moving, polymer chains, characterized mainly by their rigidity and compaction. How these pro ...[more]