Ontology highlight
ABSTRACT:
SUBMITTER: Blusztajn JK
PROVIDER: S-EPMC5579609 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Blusztajn Jan Krzysztof JK Slack Barbara E BE Mellott Tiffany J TJ
Nutrients 20170728 8
Choline is an essential nutrient for humans. It is a precursor of membrane phospholipids (e.g., phosphatidylcholine (PC)), the neurotransmitter acetylcholine, and via betaine, the methyl group donor <i>S</i>-adenosylmethionine. High choline intake during gestation and early postnatal development in rat and mouse models improves cognitive function in adulthood, prevents age-related memory decline, and protects the brain from the neuropathological changes associated with Alzheimer's disease (AD), ...[more]