Association Between IL-4 and IL-6 Expression Variants and Gastric Cancer Among Portuguese Population.

ABSTRACT:

Introduction

Multiple studies have reported strong associations between Helicobacter pylori (Hp) inflammation and gastric cancer (GC) development. Altered expressions of pro/anti-inflammatory cytokines have a crucial role in Hp and GC proliferation. Although there are many studies related to cytokines polymorphisms involvement in GC risk, the role of Interleukin-4 (IL-4) and Interleukin-6 (IL-6) in gastric inflammation process is not yet clarified.

Aim

This study aimed to investigate the impact of common IL-4 and IL-6 polymorphisms in GC development risk among Portuguese population.

Methods

A total of 100 GC biopsies (50 with intestinal type, IGC, 50 with diffuse type, DGC) and 50 chronic gastritis cases, used as control group, were included in th

SUBMITTER: Sampaio AM 

PROVIDER: S-EPMC5580160 | biostudies-literature | 2015 Jul-Aug

REPOSITORIES: biostudies-literature