Voluntary Exercise Prevents Oxidative Stress in the Brain of Phenylketonuria Mice.
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SUBMITTER: Mazzola PN
PROVIDER: S-EPMC5580734 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
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Voluntary Exercise Prevents Oxidative Stress in the Brain of Phenylketonuria Mice.
Mazzola Priscila Nicolao PN Bruinenberg Vibeke V Anjema Karen K van Vliet Danique D Dutra-Filho Carlos Severo CS van Spronsen Francjan J FJ van der Zee Eddy A EA
JIMD reports 20151007
<h4>Background</h4>High phenylalanine levels in phenylketonuria (PKU) have been associated with brain oxidative stress and amino acid imbalance. Exercise has been shown to improve brain function in hyperphenylalaninemia and neurodegenerative diseases. This study aimed to verify the effects of exercise on coordination and balance, plasma and brain amino acid levels, and brain oxidative stress markers in PKU mice.<h4>Methods</h4>Twenty wild-type (WT) and 20 PAH(enu2) (PKU) C57BL/6 mice were placed ...[more]
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