Ontology highlight
ABSTRACT:
SUBMITTER: Cortes A
PROVIDER: S-EPMC5580804 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Cortes Adrian A Dendrou Calliope A CA Motyer Allan A Jostins Luke L Vukcevic Damjan D Dilthey Alexander A Donnelly Peter P Leslie Stephen S Fugger Lars L McVean Gil G
Nature genetics 20170731 9
Genetic discovery from the multitude of phenotypes extractable from routine healthcare data can transform understanding of the human phenome and accelerate progress toward precision medicine. However, a critical question when analyzing high-dimensional and heterogeneous data is how best to interrogate increasingly specific subphenotypes while retaining statistical power to detect genetic associations. Here we develop and employ a new Bayesian analysis framework that exploits the hierarchical str ...[more]