Ontology highlight
ABSTRACT:
SUBMITTER: Bi Y
PROVIDER: S-EPMC5581077 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Oncotarget 20170516 32
There are limited strategies for the treatment of hepatocellular carcinoma (HCC). In this study, we prepared a Bispecific T cell engager (BiTE) targeting Glypican 3 (GPC3) and CD3. The GPC3/CD3 BiTE was prepared by fusing the single-chain variable fragment (scFv) of the humanized anti-GPC3 antibody (9F2) with the scFv of the anti-CD3 antibody (OKT3). The <i>in vitro</i> and <i>in vivo</i> cytotoxic activities of the GPC3/CD3 BiTE were evaluated against various HCC cell lines. The GPC3/CD3 BiTE c ...[more]