Ontology highlight
ABSTRACT:
SUBMITTER: Dong L
PROVIDER: S-EPMC6198100 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Dong Lili L Zhou Hongxin H Zhao Menglong M Gao Xinghui X Liu Yang Y Liu Dongli D Guo Wei W Hu Hongwei H Xie Qian Q Fan Jia J Lin Jiang J Wu Weizhong W
Molecular therapy. Nucleic acids 20180927
Glypican-3 (GPC3), the cellular membrane proteoglycan, has been established as a tumor biomarker for early diagnosis of hepatocellular carcinoma (HCC). GPC3 is highly expressed in more than 70% HCC tissues detected by antibody-based histopathological systems. Recently, aptamers, a short single-strand DNA or RNA generated from systematic evolution of ligands by exponential enrichment (SELEX), were reported as potential alternatives in tumor-targeted imaging and diagnosis. In this study, a total o ...[more]