Ontology highlight
ABSTRACT:
SUBMITTER: Grommes C
PROVIDER: S-EPMC5581705 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Grommes Christian C Pastore Alessandro A Palaskas Nicolaos N Tang Sarah S SS Campos Carl C Schartz Derrek D Codega Paolo P Nichol Donna D Clark Owen O Hsieh Wan-Ying WY Rohle Dan D Rosenblum Marc M Viale Agnes A Tabar Viviane S VS Brennan Cameron W CW Gavrilovic Igor T IT Kaley Thomas J TJ Nolan Craig P CP Omuro Antonio A Pentsova Elena E Thomas Alissa A AA Tsyvkin Elina E Noy Ariela A Palomba M Lia ML Hamlin Paul P Sauter Craig S CS Moskowitz Craig H CH Wolfe Julia J Dogan Ahmet A Won Minhee M Glass Jon J Peak Scott S Lallana Enrico C EC Hatzoglou Vaios V Reiner Anne S AS Gutin Philip H PH Huse Jason T JT Panageas Katherine S KS Graeber Thomas G TG Schultz Nikolaus N DeAngelis Lisa M LM Mellinghoff Ingo K IK
Cancer discovery 20170615 9
Bruton tyrosine kinase (BTK) links the B-cell antigen receptor (BCR) and Toll-like receptors with NF-κB. The role of BTK in primary central nervous system (CNS) lymphoma (PCNSL) is unknown. We performed a phase I clinical trial with ibrutinib, the first-in-class BTK inhibitor, for patients with relapsed or refractory CNS lymphoma. Clinical responses to ibrutinib occurred in 10 of 13 (77%) patients with PCNSL, including five complete responses. The only PCNSL with complete ibrutinib resistance ha ...[more]