Ontology highlight
ABSTRACT:
SUBMITTER: Lee SS
PROVIDER: S-EPMC5582136 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Lee Stephen S J SS Knott Vroni V Jovanović Jelena J Harlos Karl K Grimes Jonathan M JM Choulier Laurence L Mardon Helen J HJ Stuart David I DI Handford Penny A PA
Structure (London, England : 1993) 20040401 4
Human fibrillin-1, the major structural protein of extracellular matrix (ECM) 10-12 nm microfibrils, is dominated by 43 calcium binding epidermal growth factor-like (cbEGF) and 7 transforming growth factor beta binding protein-like (TB) domains. Crystal structures reveal the integrin binding cbEGF22-TB4-cbEGF23 fragment of human fibrillin-1 to be a Ca(2+)-rigidified tetragonal pyramid. We suggest that other cbEGF-TB pairs within the fibrillins may adopt a similar orientation to cbEGF22-TB4. In a ...[more]