Ontology highlight
ABSTRACT:
SUBMITTER: Iali W
PROVIDER: S-EPMC5582620 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Chemistry (Weinheim an der Bergstrasse, Germany) 20170719 44
Signal amplification by reversible exchange (SABRE) is shown to allow access to strongly enhanced <sup>1</sup> H NMR signals in a range of substrates in aqueous media. To achieve this outcome, phase-transfer catalysis is exploited, which leads to less than 1.5×10<sup>-6</sup> mol dm<sup>-3</sup> of the iridium catalyst in the aqueous phase. These observations reflect a compelling route to produce a saline-based hyperpolarized bolus in just a few seconds for subsequent in vivo MRI monitoring. Th ...[more]