Ontology highlight
ABSTRACT:
SUBMITTER: Kolovskaya OS
PROVIDER: S-EPMC5582647 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Kolovskaya Olga S OS Zamay Tatiana N TN Belyanina Irina V IV Karlova Elena E Garanzha Irina I Aleksandrovsky Aleksandr S AS Kirichenko Andrey A Dubynina Anna V AV Sokolov Alexey E AE Zamay Galina S GS Glazyrin Yury E YE Zamay Sergey S Ivanchenko Tatiana T Chanchikova Natalia N Tokarev Nikolay N Shepelevich Nikolay N Ozerskaya Anastasia A Badrin Evgeniy E Belugin Kirill K Belkin Simon S Zabluda Vladimir V Gargaun Ana A Berezovski Maxim V MV Kichkailo Anna S AS
Molecular therapy. Nucleic acids 20170816
Novel nanoscale bioconjugates combining unique plasmonic photothermal properties of gold nanoparticles (AuNPs) with targeted delivery using cell-specific DNA aptamers have a tremendous potential for medical diagnostics and therapy of many cell-based diseases. In this study, we demonstrate the high anti-cancer activity of aptamer-conjugated, 37-nm spherical gold nanoparticles toward Ehrlich carcinoma in tumor-bearing mice after photothermal treatment. The synthetic anti-tumor aptamers bring the n ...[more]