Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC3407577 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
ACS nano 20120604 6
An aptamer switch probe (ASP) linking chlorin e6 (Ce6), a photosensitizer molecule, to the surface of gold nanorods (AuNRs) was used to target cancer cells for photodynamic therapy (PDT) and photothermal therapy (PTT). In the presence of target cancer cells, the ASP changes conformation to drive Ce6 away from the gold surface, thereby producing singlet oxygen for PDT upon light irradiation. Since each AuNR is modified with many ASP-Ce6 molecules, the AuNR-ASP-Ce6 conjugate yields enhanced bindin ...[more]