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ABSTRACT:
SUBMITTER: Golan-Mashiach M
PROVIDER: S-EPMC3333863 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Golan-Mashiach Michal M Grunspan Moshe M Emmanuel Rafi R Gibbs-Bar Liron L Dikstein Rivka R Shapiro Ehud E
Nucleic acids research 20111230 8
The brain is a large and complex network of neurons. Specific neuronal connectivity is thought to be based on the combinatorial expression of the 52 protocadherins (Pcdh) membrane adhesion proteins, whereby each neuron expresses only a specific subset. Pcdh genes are arranged in tandem, in a cluster of three families: Pcdhα, Pcdhβ and Pcdhγ. The expression of each Pcdh gene is regulated by a promoter that has a regulatory conserved sequence element (CSE), common to all 52 genes. The mechanism an ...[more]