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Functional roles of p120ctn family of proteins in central neurons.

ABSTRACT: The cadherin-catenin complex in central neurons is associated with a variety of cytosolic partners, collectively called catenins. The p120ctn members are a family of catenins that are distinct from the more ubiquitously expressed ?- and ?-catenins. It is becoming increasingly clear that the functional roles of the p120ctn family of catenins in central neurons extend well beyond their functional roles in non-neuronal cells in partnering with cadherin to regulate adhesion. In this review, we will provide an overview of the p120ctn family in neurons and their varied functional roles in central neurons. Finally, we will examine the emerging roles of this family of proteins in neurodevelopmental disorders.

SUBMITTER: Yuan L

PROVIDER: S-EPMC5583011 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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Functional roles of p120ctn family of proteins in central neurons.

Yuan Li L Arikkath Jyothi J

Seminars in cell & developmental biology 20170609

The cadherin-catenin complex in central neurons is associated with a variety of cytosolic partners, collectively called catenins. The p120ctn members are a family of catenins that are distinct from the more ubiquitously expressed α- and β-catenins. It is becoming increasingly clear that the functional roles of the p120ctn family of catenins in central neurons extend well beyond their functional roles in non-neuronal cells in partnering with cadherin to regulate adhesion. In this review, we will ...[more]

PMID: 28603076

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