Ontology highlight
ABSTRACT:
SUBMITTER: Ozato K
PROVIDER: S-EPMC3433745 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Nature reviews. Immunology 20081101 11
The superfamily of tripartite motif-containing (TRIM) proteins is conserved throughout the metazoan kingdom and has expanded rapidly during vertebrate evolution; there are now more than 60 TRIM proteins known in humans and mice. Many TRIM proteins are induced by type I and type II interferons, which are crucial for many aspects of resistance to pathogens, and several are known to be required for the restriction of infection by lentiviruses. In this Review, we describe recent data that reveal bro ...[more]