Ontology highlight
ABSTRACT:
SUBMITTER: Liu M
PROVIDER: S-EPMC5583183 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Liu Min M Liang Kaili K Zhen Junhui J Zhou Meng M Wang Xiaojie X Wang Ziying Z Wei Xinbing X Zhang Yan Y Sun Yu Y Zhou Zhuanli Z Su Hua H Zhang Chun C Li Ningjun N Gao Chengjiang C Peng Jun J Yi Fan F
Nature communications 20170904 1
Podocyte injury is a major determinant of proteinuric kidney disease and the identification of potential therapeutic targets for preventing podocyte injury has clinical importance. Here, we show that histone deacetylase Sirt6 protects against podocyte injury through epigenetic regulation of Notch signaling. Sirt6 is downregulated in renal biopsies from patients with podocytopathies and its expression correlates with glomerular filtration rate. Podocyte-specific deletion of Sirt6 exacerbates podo ...[more]