Ontology highlight
ABSTRACT:
SUBMITTER: Yamada S
PROVIDER: S-EPMC3934867 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Yamada Sachiko S Nakamura Jin J Asada Misako M Takase Masayuki M Matsusaka Taiji T Iguchi Taku T Yamada Ryo R Tanaka Mari M Higashi Atsuko Y AY Okuda Tomohiko T Asada Nariaki N Fukatsu Atsushi A Kawachi Hiroshi H Graf Daniel D Muso Eri E Kita Toru T Kimura Takeshi T Pastan Ira I Economides Aris N AN Yanagita Motoko M
PloS one 20140225 2
Podocyte injury is the first step in the progression of glomerulosclerosis. Previous studies have demonstrated the beneficial effect of bone morphogenetic protein 7 (Bmp7) in podocyte injury and the existence of native Bmp signaling in podocytes. Local activity of Bmp7 is controlled by cell-type specific Bmp antagonists, which inhibit the binding of Bmp7 to its receptors. Here we show that the product of Twisted gastrulation (Twsg1), a Bmp antagonist, is the central negative regulator of Bmp fun ...[more]