Ontology highlight
ABSTRACT:
SUBMITTER: Kumar A
PROVIDER: S-EPMC5583329 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Kumar Abhishek A Bhandari Anita A Sarde Sandeep J SJ Goswami Chandan C
Scientific reports 20170904 1
HSP47/SERPINH1 is key-regulator for collagen biosynthesis and its structural assembly. To date, there is no comprehensive study on the phylogenetic history of HSP47. Herein we illustrate the evolutionary history of HSP47/SERPINH1 along with sequence, structural and syntenic traits for HSP47/SERPINH1. We have identified ancestral HSP47/SERPINH1 locus in Japanese lamprey (Lethenteron japonicum). This gene remains on the same or similar locus for ~500 million years (MY), but chromosomal duplication ...[more]