Ontology highlight
ABSTRACT:
SUBMITTER: Dooley J
PROVIDER: S-EPMC5584070 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Nature genetics 20160321 5
Type 1 (T1D) and type 2 (T2D) diabetes share pathophysiological characteristics, yet mechanistic links have remained elusive. T1D results from autoimmune destruction of pancreatic beta cells, whereas beta cell failure in T2D is delayed and progressive. Here we find a new genetic component of diabetes susceptibility in T1D non-obese diabetic (NOD) mice, identifying immune-independent beta cell fragility. Genetic variation in Xrcc4 and Glis3 alters the response of NOD beta cells to unfolded protei ...[more]