Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Pancreatic Islet
SUBMITTER: Jonathan Vandenbussche
LAB HEAD: Kris Gevaert
PROVIDER: PXD000859 | Pride | 2016-02-24
REPOSITORIES: Pride
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Dooley James J Tian Lei L Schonefeldt Susann S Delghingaro-Augusto Viviane V Garcia-Perez Josselyn E JE Pasciuto Emanuela E Di Marino Daniele D Carr Edward J EJ Oskolkov Nikolay N Lyssenko Valeriya V Franckaert Dean D Lagou Vasiliki V Overbergh Lut L Vandenbussche Jonathan J Allemeersch Joke J Chabot-Roy Genevieve G Dahlstrom Jane E JE Laybutt D Ross DR Petrovsky Nikolai N Socha Luis L Gevaert Kris K Jetten Anton M AM Lambrechts Diether D Linterman Michelle A MA Goodnow Chris C CC Nolan Christopher J CJ Lesage Sylvie S Schlenner Susan M SM Liston Adrian A
Nature genetics 20160321 5
Type 1 (T1D) and type 2 (T2D) diabetes share pathophysiological characteristics, yet mechanistic links have remained elusive. T1D results from autoimmune destruction of pancreatic beta cells, whereas beta cell failure in T2D is delayed and progressive. Here we find a new genetic component of diabetes susceptibility in T1D non-obese diabetic (NOD) mice, identifying immune-independent beta cell fragility. Genetic variation in Xrcc4 and Glis3 alters the response of NOD beta cells to unfolded protei ...[more]