Ontology highlight
ABSTRACT:
SUBMITTER: Howes SC
PROVIDER: S-EPMC5584162 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
The Journal of cell biology 20170626 9
Microtubules are polymers of αβ-tubulin heterodimers essential for all eukaryotes. Despite sequence conservation, there are significant structural differences between microtubules assembled in vitro from mammalian or budding yeast tubulin. Yeast MTs were not observed to undergo compaction at the interdimer interface as seen for mammalian microtubules upon GTP hydrolysis. Lack of compaction might reflect slower GTP hydrolysis or a different degree of allosteric coupling in the lattice. The microt ...[more]