Ontology highlight
ABSTRACT:
SUBMITTER: Schmiege P
PROVIDER: S-EPMC6105560 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
The FEBS journal 20180414 14
Transient receptor potential mucolipin (TRPML) channels are the most recently identified subfamily of TRP channels and have seen a surge of new reports revealing both structural and functional insight. In 2017, several groups published multiple conformations of TRPML channels using cryo-EM. Similar to other TRP channels, the ML subfamily consists of six transmembrane helices (S1-S6), and a pore region including S5, S6, and two pore helices (PH1 and PH2). However, these reports also reveal distin ...[more]