Ontology highlight
ABSTRACT:
SUBMITTER: Larder R
PROVIDER: S-EPMC5584443 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20170815 35
An intergenic region of human chromosome 2 (2p25.3) harbors genetic variants which are among those most strongly and reproducibly associated with obesity. The gene closest to these variants is <i>TMEM18</i>, although the molecular mechanisms mediating these effects remain entirely unknown. <i>Tmem18</i> expression in the murine hypothalamic paraventricular nucleus (PVN) was altered by changes in nutritional state. Germline loss of <i>Tmem18</i> in mice resulted in increased body weight, which wa ...[more]