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Regulation of appetite to treat obesity.


ABSTRACT: Obesity has escalated into a pandemic over the past few decades. In turn, research efforts have sought to elucidate the molecular mechanisms underlying the regulation of energy balance. A host of endogenous mediators regulate appetite and metabolism, and thereby control both short- and long-term energy balance. These mediators, which include gut, pancreatic and adipose neuropeptides, have been targeted in the development of anti-obesity pharmacotherapy, with the goal of amplifying anorexigenic and lipolytic signaling or blocking orexigenic and lipogenic signaling. This article presents the efficacy and safety of these anti-obesity drugs.

SUBMITTER: Kim GW 

PROVIDER: S-EPMC3111219 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Regulation of appetite to treat obesity.

Kim Gilbert W GW   Lin Jieru E JE   Valentino Michael A MA   Colon-Gonzalez Francheska F   Waldman Scott A SA  

Expert review of clinical pharmacology 20110301 2


Obesity has escalated into a pandemic over the past few decades. In turn, research efforts have sought to elucidate the molecular mechanisms underlying the regulation of energy balance. A host of endogenous mediators regulate appetite and metabolism, and thereby control both short- and long-term energy balance. These mediators, which include gut, pancreatic and adipose neuropeptides, have been targeted in the development of anti-obesity pharmacotherapy, with the goal of amplifying anorexigenic a  ...[more]

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