Regulation of appetite to treat obesity.
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ABSTRACT:
SUBMITTER: Kim GW
PROVIDER: S-EPMC3111219 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Publications
Regulation of appetite to treat obesity.
Kim Gilbert W GW Lin Jieru E JE Valentino Michael A MA Colon-Gonzalez Francheska F Waldman Scott A SA
Expert review of clinical pharmacology 20110301 2
Obesity has escalated into a pandemic over the past few decades. In turn, research efforts have sought to elucidate the molecular mechanisms underlying the regulation of energy balance. A host of endogenous mediators regulate appetite and metabolism, and thereby control both short- and long-term energy balance. These mediators, which include gut, pancreatic and adipose neuropeptides, have been targeted in the development of anti-obesity pharmacotherapy, with the goal of amplifying anorexigenic a ...[more]
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