Ontology highlight
ABSTRACT:
SUBMITTER: Rabaa MA
PROVIDER: S-EPMC5584992 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Rabaa Maia A MA Girerd-Chambaz Yves Y Duong Thi Hue Kien K Vu Tuan Trung T Wills Bridget B Bonaparte Matthew M van der Vliet Diane D Langevin Edith E Cortes Margarita M Zambrano Betzana B Dunod Corinne C Wartel-Tram Anh A Jackson Nicholas N Simmons Cameron P CP
eLife 20170905
This study defined the genetic epidemiology of dengue viruses (DENV) in two pivotal phase III trials of the tetravalent dengue vaccine, CYD-TDV, and thereby enabled virus genotype-specific estimates of vaccine efficacy (VE). Envelope gene sequences (n = 661) from 11 DENV genotypes in 10 endemic countries provided a contemporaneous global snapshot of DENV population genetics and revealed high amino acid identity between the E genes of vaccine strains and wild-type viruses from trial participants, ...[more]