Ontology highlight
ABSTRACT:
SUBMITTER: Juraska M
PROVIDER: S-EPMC6130398 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Juraska Michal M Magaret Craig A CA Shao Jason J Carpp Lindsay N LN Fiore-Gartland Andrew J AJ Benkeser David D Girerd-Chambaz Yves Y Langevin Edith E Frago Carina C Guy Bruno B Jackson Nicholas N Duong Thi Hue Kien K Simmons Cameron P CP Edlefsen Paul T PT Gilbert Peter B PB
Proceedings of the National Academy of Sciences of the United States of America 20180820 36
Two phase 3 placebo-controlled trials of the CYD-TDV vaccine, evaluated in children aged 2-14 y (CYD14) and 9-16 y (CYD15), demonstrated vaccine efficacy (VE) of 56.5% and 60.8%, respectively, against symptomatic virologically confirmed dengue (VCD). Sieve analyses were conducted to evaluate whether and how VE varied with amino acid sequence features of dengue viruses (DENVs). DENV premembrane/envelope amino acid sequences from VCD endpoint cases were aligned with the vaccine insert sequences, a ...[more]