Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy.
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ABSTRACT:
SUBMITTER: Turkiew E
PROVIDER: S-EPMC5585053 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Publications
Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy.
Turkiew Elliot E Falconer Debbie D Reed Nicole N Höke Ahmet A
Journal of the peripheral nervous system : JPNS 20170901 3
Distal axon degeneration seen in many peripheral neuropathies is likely to share common molecular mechanisms with Wallerian degeneration. Although several studies in mouse models of peripheral neuropathy showed prevention of axon degeneration in the slow Wallerian degeneration (Wlds) mouse, the role of a recently identified player in Wallerian degeneration, Sarm1, has not been explored extensively. In this study, we show that mice lacking the Sarm1 gene are resistant to distal axonal degeneratio ...[more]
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