Ontology highlight
ABSTRACT:
SUBMITTER: Yeku OO
PROVIDER: S-EPMC5585170 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Yeku Oladapo O OO Purdon Terence J TJ Koneru Mythili M Spriggs David D Brentjens Renier J RJ
Scientific reports 20170905 1
Chimeric antigen receptor (CAR) T cell therapy has shown limited efficacy for the management of solid tumor malignancies. In ovarian cancer, this is in part due to an immunosuppressive cytokine and cellular tumor microenvironment which suppresses adoptively transferred T cells. We engineered an armored CAR T cell capable of constitutive secretion of IL-12, and delineate the mechanisms via which these CAR T cells overcome a hostile tumor microenvironment. In this report, we demonstrate enhanced p ...[more]