Ontology highlight
ABSTRACT:
SUBMITTER: Haile LA
PROVIDER: S-EPMC5585229 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Haile Lydia Asrat LA Polumuri Swamy Kumar SK Rao Roshni R Kelley-Baker Logan L Kryndushkin Dimitri D Rajaiah Rajesh R Israely Tomer T Rao V Ashutosh VA Verthelyi Daniela D
Scientific reports 20170905 1
Immunogenicity can have devastating consequences on the safety and efficacy of therapeutic proteins. Therefore, evaluating and mitigating the risk of product immunogenicity is critical for the development these products. This study, showed that Betaseron and Extavia, which are reported to be more immunogenic among IFNβ products in clinical usage, contain residual innate immune response modulating impurities (IIRMIs) capable of activating NF-κB and induced expression of inflammatory mediators. Th ...[more]