Ontology highlight
ABSTRACT:
SUBMITTER: Dyall J
PROVIDER: S-EPMC5853567 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Dyall Julie J Hart Brit J BJ Postnikova Elena E Cong Yu Y Zhou Huanying H Gerhardt Dawn M DM Freeburger Denise D Michelotti Julia J Honko Anna N AN DeWald Lisa Evans LE Bennett Richard S RS Olinger Gene G GG Jahrling Peter B PB Hensley Lisa E LE
The Journal of infectious diseases 20170501 9
Previous studies have demonstrated little efficacy of interferons (IFNs) in animal models of Ebola virus disease. However, these studies were limited to a small number of type I IFNs and, during the most recent outbreak of Ebola virus, questions regarding the suitability of the animal models to evaluate IFNs were raised. To address the potential that anti-Ebola virus activity was overlooked, type I and type II IFNs (α-2a, α-2b, -β, -γ, and -universal) were tested in a variety of cell types (Vero ...[more]