Ontology highlight
ABSTRACT:
SUBMITTER: Thunemann M
PROVIDER: S-EPMC5585248 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Thunemann Martin M Schörg Barbara F BF Feil Susanne S Lin Yun Y Voelkl Jakob J Golla Matthias M Vachaviolos Angelos A Kohlhofer Ursula U Quintanilla-Martinez Leticia L Olbrich Marcus M Ehrlichmann Walter W Reischl Gerald G Griessinger Christoph M CM Langer Harald F HF Gawaz Meinrad M Lang Florian F Schäfers Michael M Kneilling Manfred M Pichler Bernd J BJ Feil Robert R
Nature communications 20170905 1
Many pathophysiological processes are associated with proliferation, migration or death of distinct cell populations. Monitoring specific cell types and their progeny in a non-invasive, longitudinal and quantitative manner is still challenging. Here we show a novel cell-tracking system that combines Cre/lox-assisted cell fate mapping with a thymidine kinase (sr39tk) reporter gene for cell detection by positron emission tomography (PET). We generate Rosa26-mT/sr39tk PET reporter mice and induce s ...[more]