Ontology highlight
ABSTRACT:
SUBMITTER: Zitti B
PROVIDER: S-EPMC5585267 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Zitti Beatrice B Molfetta Rosa R Fionda Cinzia C Quatrini Linda L Stabile Helena H Lecce Mario M de Turris Valeria V Ricciardi Maria Rosaria MR Petrucci Maria Teresa MT Cippitelli Marco M Gismondi Angela A Santoni Angela A Paolini Rossella R
Scientific reports 20170905 1
Natural Killer cells are innate lymphocytes involved in tumor immunosurveillance. They express activating receptors able to recognize self-molecules poorly expressed on healthy cells but up-regulated upon stress conditions, including transformation. Regulation of ligand expression in tumor cells mainly relays on transcriptional mechanisms, while the involvement of ubiquitin or ubiquitin-like modifiers remains largely unexplored. Here, we focused on the SUMO pathway and demonstrated that the liga ...[more]