Ontology highlight
ABSTRACT:
SUBMITTER: Gardner B
PROVIDER: S-EPMC5585381 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Gardner Bronwen B Dieriks Birger V BV Cameron Steve S Mendis Lakshini H S LHS Turner Clinton C Faull Richard L M RLM Curtis Maurice A MA
Scientific reports 20170905 1
In Parkinson's disease (PD), the olfactory bulb is typically the first region in the body to accumulate alpha-synuclein aggregates. This pathology is linked to decreased olfactory ability, which becomes apparent before any motor symptoms occur, and may be due to a local metal imbalance. Metal concentrations were investigated in post-mortem olfactory bulbs and tracts from 17 human subjects. Iron (p < 0.05) and sodium (p < 0.01) concentrations were elevated in the PD olfactory bulb. Combining lase ...[more]