Dataset Information

Olfactory bulb proteomics in human Alzheimer's disease

ABSTRACT: Olfactory dysfunction is among the earliest features of Alzheimer´s disease (AD). Although neuropathological abnormalities have been detected in the olfactory bulb (OB), little is known about its dynamic biology. Here, OB- proteome analysis was performed across different AD stages using a label-free approach.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

SUBMITTER: Enrique SantamarÃa

LAB HEAD: ENRIQUE SANTAMARIA

PROVIDER: PXD005319 | Pride | 2018-01-16

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	0046-028-Label-Free-Mercedes-28012016-7.group	Other
	0046-028-Label-Free-Mercedes-28012016-7.wiff	Wiff
	0046-028-Label-Free-Mercedes-28012016-7.wiff.scan	Wiff
	0046-028-Label-Free-Mercedes-28012016-7__FDR.xlsx	Xlsx
	0067-028-Label-Free-Mercedes-28012016-16.group	Other

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Publications

Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer's disease progression.

Lachén-Montes Mercedes M González-Morales Andrea A Zelaya María Victoria MV Pérez-Valderrama Estela E Ausín Karina K Ferrer Isidro I Fernández-Irigoyen Joaquín J Santamaría Enrique E

Scientific reports 20170822 1

Olfactory dysfunction is among the earliest features of Alzheimer's disease (AD). Although neuropathological abnormalities have been detected in the olfactory bulb (OB), little is known about its dynamic biology. Here, OB- proteome analysis showed a stage-dependent synaptic proteostasis impairment during AD evolution. In addition to progressive modulation of tau and amyloid precursor protein (APP) interactomes, network-driven proteomics revealed an early disruption of upstream and downstream p38 ...[more]

PMID: 28831118

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